The Health Ministry in Gaza said at least 51 people were killed and 82 wounded in the operation in Khan Younis that began early Wednesday. Records at the European Hospital show that seven women and 12 children, as young as 22 months old, were among those killed.
Another 23 people, including two children, were killed in separate strikes across Gaza, according to local hospitals.
The Israeli military did not immediately respond to a request for comment.
Residents said Israel had carried out heavy airstrikes as its ground forces staged an incursion into three neighborhoods in Khan Younis. Mahmoud al-Razd, a resident who said four relatives were killed in the raids, described heavy destruction and said first responders had struggled to reach destroyed homes.
“The explosions and shelling were massive,” he told The Associated Press. “Many people are thought to be under the rubble, and no one can retrieve them.”
Israel carried out a weekslong offensive earlier this year in Khan Younis that left much of Gaza's second largest city in ruins. Over the course of the war, Israeli forces have repeatedly returned to areas of Gaza where they have previously fought Hamas and other armed groups as the militants have regrouped.
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