Syria’s banned Muslim Brotherhood on Friday lashed out at Prime Minister Najib Miqati, accusing him of “siding with the killers of Syrian children.”

In a statement published by the Italian news agency AKI, the Brotherhood’s official spokesman Zuheir Salem said “the Syrian people would never compromise, no matter the sacrifices, the blood of our brothers in Lebanon, whether in Tripoli, Beirut, Sidon … or anywhere in Lebanon.”

The United States on Thursday stepped up the pressure on Syria over its crackdown on pro-democracy protesters, imposing sanctions on a businessman close to President Bashar al-Assad and his family.

The move freezes the U.S. assets of Mohammed Hamsho and his company, Hamsho International Group, and prohibits U.S. entities from engaging in any business dealings with them, the Treasury Department said in a statement.

The United States warned Thursday that President Bashar al-Assad had put Syria and the Middle East on a "very dangerous path," again toughening rhetoric on a crackdown by Damascus.

Washington appears to be moving towards a first direct call for Assad to go, a step it has so far resisted, and is preparing a new round of sanctions against his regime after an escalation of violence in the revolt hub of Hama.

EU foreign policy chief Catherine Ashton on Thursday dubbed Syria's multi-party reform offer "a step in the right direction" but on condition it be put into effect.

"We are still waiting for previously announced reforms to be implemented," Ashton said in a statement issued after President Bashar al-Assad issued a decree allowing opposition political parties.

Syrian dissidents and activists said Thursday President Bashar al-Assad's decision to allow opposition political parties was a political ploy, and that constitutional change is the only way to democracy.

"The regime is not serious about transforming the country from a dominant party into democracy and pluralism. Instead, it is trying to carry out some cosmetic work to improve its image," Anwar al-Bunni, head of the Syrian Center for Studies and Legal Research, told Agence France Presse.

Russian President Dmitry Medvedev on Thursday called the situation in Syria "dramatic" and expressed "enormous concern" over the deadly violence in the country.

"Unfortunately, people die there in large numbers. This arouses enormous concern from us," the Russian leader said in an interview given to Russian media in the southern resort Sochi.

Syria's embattled president on Thursday decreed a law allowing opposition political parties, state media said after the United Nations condemned his regime's deadly crackdown on democracy protests.

"President Bashar Assad on Thursday issued Legislative Decree No. 100 for 2011 on Parties Law and Legislative Decree No. 101 for 2011 on General Election Law," the official SANA news agency said in a brief report.

The United States Wednesday said it had no interest in seeing Syria's President Bashar al-Assad survive simply to preserve regional "stability," hardening its line on what it termed a "grotesque" crackdown on dissent.

Some analysts have speculated that Washington has been wary of directly calling for Assad to quit because of anxiety that security chaos, civil war and a Middle East power vacuum might follow the demise of his regime.

Syrian dissidents on Tuesday urged U.S. President Barack Obama to call on Syrian leader Bashar al-Assad to quit power and to press for U.N. sanctions over his regime's deadly crackdown on protests.

The demands -- presented in a first meeting between U.S. Secretary Clinton and members of Syria's disparate opposition -- added to U.S. domestic pressure on the Obama administration to take a tougher line against Assad's regime.

Germany Monday condemned what it called a war by the Syrian government against its own people, after calling for a meeting of the United Nations Security Council on the latest deadly crackdown.

Foreign ministry spokesman Martin Schaefer renewed Berlin's call for a robust response from the council and new European Union sanctions against Damascus after activists said security forces killed nearly 140 people Sunday.