The United States is shifting military resources, including ships, in the Middle East in response to Israel's strikes on Iran and a possible retaliatory attack by Tehran, two U.S. officials said Friday.

The Navy has directed the destroyer USS Thomas Hudner, which is capable of defending against ballistic missiles, to begin sailing from the western Mediterranean Sea toward the eastern Mediterranean and has directed a second destroyer to begin moving forward so it can be available if requested by the White House.

Israel targeted leading members of Iran's armed forces on Friday during its unprecedented onslaught hitting military and nuclear targets across the country.

Here is what we know about some of the top figures killed:

Israel's massive strike on Iran on Friday morning came after decades of mutual hostility and a long-running shadow war of covert strikes and sabotage.

Israeli Prime Minister Benjamin Netanyahu has long identified Iran as its greatest threat, citing the country's nuclear program, its hostile rhetoric and support for anti-Israel militant groups across the region. Iran has championed the Palestinian cause and portrayed Israel as a malicious Western encroachment on the Middle East.

Iran's Revolutionary Guards confirmed that its aerospace commander had been killed with fellow officers in an Israeli air strike on their command center on Friday.

"Commander of the Islamic Revolutionary Guards Corps aerospace force Major General Amirali Hajizadeh... along with a group of brave and dedicated fighters of this force, were martyred" in an Israeli attack on their command center, the Guards said in a statement.

A fresh round of explosions was heard in northwestern Iran on Friday, state television reported, after Israel carried out a wave of strikes on multiple cities.

Israel launched fresh attacks on a key underground uranium enrichment facility in central Iran on Friday, Iranian state media reported.

U.S. President Donald Trump urged Iran on Friday to "make a deal," warning that there will be more "death and destruction" after Israel launched deadly strikes targeting Iranian nuclear facilities.

His comments on his Truth Social platform came after Israel pounded Iran in a series of air raids on Friday, striking 100 targets.

Israel's defense ministry said Friday that Israeli air strikes across Iran had "neutralized" most of the senior leadership of the Iranian Revolutionary Guards' Air Force.

"The defense minister was informed that most of the Revolutionary Guard Air Force leadership was neutralized while convening at their underground headquarters," the ministry said in a statement.

U.S. President Donald Trump told Fox News he was aware Israel was going to conduct strikes on Iran before it happened, and stressed that Tehran "cannot have a nuclear bomb," according to the US broadcaster.

His comments to Fox came after Israel pounded Iran in a series of air raids on Friday, striking 100 targets including nuclear and military sites.

Iran's supreme leader Ayatollah Ali Khamenei swiftly appointed new Revolutionary Guards and armed forces chiefs to replace those killed in targeted Israeli strikes on Friday.

In separate decrees, Khamenei named Mohammad Pakpour to replace Hossein Salami as commander of the Islamic Revolutionary Guard Corps, and Abdolrahim Mousavi to replace Mohammad Bagheri as chief of the armed forces general staff.

The Israeli military said it hit the underground uranium enrichment centrifuges at Iran's vast Natanz facility as part of the wave of strikes it carried out on Friday.

"The underground area of the site was damaged. This area contains a multi-storey enrichment hall with centrifuges, electrical rooms and additional supporting infrastructure," the military said in a statement.