Israel is almost certain to retaliate at some stage against Iran's unprecedented drone and missile attack, but the question is how and when, say security analysts.

World leaders have urged calm and the United States, Israel's top ally, called on Israel to refrain from a military response, at a time when the region is already in turmoil over the Gaza war.

They set themselves a 48-hour deadline earlier this week, but on Thursday neither Hamas nor Israel had shown any signs of agreeing to a truce in Gaza despite pressure from international mediators.

The United States, Egypt and Qatar put together a framework for a deal that would include a six-week halt to fighting and the exchange of about 40 hostages for hundreds of Palestinian prisoners.

The bloodiest ever war in Gaza that broke out exactly six months ago has taken an appalling human toll.

At least 33,175 people have been killed in the besieged Palestinian territory in Israel's campaign of retaliation for the October 7 attack.

At the start of Israel's war with Hamas in October, Donald Trump loudly presented himself as the key U.S. ally's ultimate champion.

World Central Kitchen, the food charity founded by celebrity chef José Andrés, called a halt to its work in the Gaza Strip after an apparent Israeli strike killed seven of its workers, mostly foreigners.

The group, which said it will make decisions about longer-term plans in the region soon, has been bringing desperately-needed food to Gazans facing widespread hunger and pioneered the recently launched effort to deliver aid by sea from Cyprus. Its absence, even if temporary, is likely to deepen the war-torn territory's misery as the United Nations warns that famine is imminent.

A deadly strike blamed on Israel against Iran's diplomatic mission in Damascus could trigger a spillover of the Gaza war across the region, an escalation Tehran had sought to avoid, analysts said.

Monday's strike levelled the consular annex of the Iranian embassy and killed 13 people, including seven members of Iran's Islamic Revolutionary Guard Corps (IRGC), Iranian state media reported.

The huge gains made by the opposition in Turkey's local elections are raising the possibility that the long-serving President Recep Tayyip Erdogan and his ruling party could step back from some of the populist leader's more polarizing policies ahead of the next round of voting in four years' time.

There is no doubt that Sunday's local polls were a blow to both Erdogan and his Islamic-oriented Justice and Development Party, or AKP, which won last year's presidential and parliamentary elections.

Israel launched deadly cross-border strikes Friday on Hezbollah targets in Syria and Lebanon, doubling down on Iran-backed foes and Hamas allies, and fuelling concerns the violence could spark a major regional conflagration.

The Israeli army said it killed the deputy head of Hezbollah's rocket unit, Ali Naim, in one of the attacks on southern Lebanon.

The nun stood in front of a group of young students at a Lebanese Christian school and asked them to pray for the "men of the resistance" in southern Lebanon who she said were defending the country.

The men to whom nun Maya Ziadeh was referring are members of the Lebanese Shiite militant group Hezbollah, which has been clashing with Israel across a volatile border for nearly six months, becoming a critical regional player as the Israel-Hamas war persists in Gaza.

Jamaa Islamiya has a much lower profile than other militant groups in Lebanon, but the escalation of strikes over the border with Israel is pushing it into the spotlight.

Formed in the 1960s, Jamaa Islamiya claims to have carried out operations with Palestinian militant group Hamas in southern Lebanon and said seven affiliated rescuers were killed in an overnight Israeli strike.