With his major opponents imprisoned or left off the ballot, Tunisian President Kais Saied faces few obstacles to winning reelection on Sunday, five years after riding anti-establishment backlash to a first term.

The North African country's Oct. 6 presidential election is its third since protests led to the 2011 ouster of President Zine El Abidine Ben Ali — the first autocrat toppled in the Arab Spring uprisings that also overthrew leaders in Egypt, Libya and Yemen.

Iran's supreme leader Ayatollah Ali Khamenei delivered remarks in Arabic in a rare Friday sermon after the Farsi-speaking Islamic republic had launched a missile attack on foe Israel.

During the sermon at a mosque in Tehran, Khamenei hailed Iran-backed armed group Hezbollah and Hamas, which are both fighting Israel and operate in Arabic-speaking Lebanon and the Gaza Strip, respectively.

The Israeli military on Thursday said a strike three months ago killed three senior Hamas leaders in Gaza, where the army has been battling the Palestinian militants for nearly a year.

The military said the strike killed Rawhi Mushtaha, the head of the Hamas government in the Gaza Strip, and Sameh al-Siraj, who held the security portfolio for Hamas's political bureau, and Sami Oudeh, a commander.

An Israeli air strike killed two people in Damascus Wednesday, a monitor said, in the second strike in two days on a neighborhood that is home to security headquarters and embassies.

"An Israeli air strike targeted a residential building in the Mazzeh neighborhood frequented by Hezbollah leaders and the Iranian Revolutionary Guards," killing at least two people whose identity was not immediately clear, the Britain-based Syrian Observatory for Human Rights said.

The U.S. has imposed sanctions on an Iranian man and three Chinese firms that Washington believes helped the Houthi militant group acquire materials needed to manufacture and deploy advanced missiles and drones against the U.S. and its allies.

Iranian citizen Hasan Ahmad Hasan Muhammad al-Kuhlani is named in the sanctions announced Wednesday. He is accused of facilitating weapons smuggling for the Houthis.

World leaders called on Iran and Israel to step back from the brink after Tehran fired a barrage of rockets at its arch-rival.

Tehran said Tuesday's attack -- launched as Israel said it was mounting a ground offensive against Iran-backed Hezbollah in Lebanon -- was in response to the killings of Iran-backed militant leaders.

Israel on Wednesday declared U.N. chief Antonio Guterres "persona non grata", banning him from entering the country for failing to condemn Iran's missile attack on Israel.

"Anyone who cannot unequivocally condemn Iran's heinous attack on Israel does not deserve to step foot on Israeli soil. This is an anti-Israel Secretary-General who lends support to terrorists, rapists, and murderers," said Foreign Minister Israel Katz in a statement.

The Health Ministry in Gaza said at least 51 people were killed and 82 wounded in the operation in Khan Younis that began early Wednesday. Records at the European Hospital show that seven women and 12 children, as young as 22 months old, were among those killed.

Another 23 people, including two children, were killed in separate strikes across Gaza, according to local hospitals.

The Biden administration says there is a significant difference between Israeli actions that have expanded its war against the Iranian-backed militant groups Hamas and Hezbollah and Iran's retaliatory missile attack against Israel, which it condemned as escalatory.

In carefully calibrated remarks, officials across the administration are defending the surge in attacks by Israel against Hezbollah leaders in Lebanon, while still pressing for peace and vowing retribution after Iran fired about 200 ballistic missiles at Israel on Tuesday.

Israeli police said on Wednesday that a total of seven people were killed in a shooting attack in Tel Aviv on Tuesday evening minutes before the Iranian missile barrage.

Two Palestinian men from the Israeli-occupied West Bank city of Hebron opened fire in the Jaffa neighborhood of Tel Aviv, including shooting directly into a light rail carriage crowded with passengers that was stopped at a station.